abstract：:In this randomized, controlled, open-label, phase IV study, ovarian response after a follitropin alfa starting dose determined by the CONSORT calculator was compared with a standard dose (150 IU). Normo-ovulatory women (aged 18-34 years) eligible for assisted reproductive techniques were recruited (23 centres: nine Eu...

journal_title：Reproductive biomedicine online

authors： Olivennes F,Trew G,Borini A,Broekmans F,Arriagada P,Warne DW,Howles CM

更新日期：2015-03-01 00:00:00

abstract：:The efficiency of a new vitrification technique using embryos obtained after abnormal fertilization was assesed. A total of 100 embryos were vitrified, 48 with the automatic dehydrated carrier (ADC) technique and 52 with cryotop. The survival rates in ADC and cryotop groups were similar (85.4% versus 92.3%). The loss ...

journal_title：Reproductive biomedicine online

authors： Zhang X,Liu J,Huang G

更新日期：2015-02-01 00:00:00

abstract：:The effect of N-acetylcysteine (NAC) on mouse ovary heterotopic autotransplantation was investigated. Mice (age 4-5 weeks) were divided into the following groups: control; autograft plus NAC (150 mg/kg daily intraperitoneal injection) and autograft plus saline (n = 6 per group). Groups were treated from 1 day before u...

journal_title：Reproductive biomedicine online

authors： Mahmoodi M,Soleimani Mehranjani M,Shariatzadeh SM,Eimani H,Shahverdi A

更新日期：2015-01-01 00:00:00

abstract：:The clinical implications of congenital uterine anomalies (CUA), and the benefits of hysteroscopic resection of a uterine septum, were evaluated. Studies comparing reproductive and obstetric outcome of patients with and without CUA and of patients who had and had not undergone hysteroscopic resection of a uterine sept...

journal_title：Reproductive biomedicine online

authors： Venetis CA,Papadopoulos SP,Campo R,Gordts S,Tarlatzis BC,Grimbizis GF

更新日期：2014-12-01 00:00:00

abstract：:An increasing number of infertile syphilis-infected individuals have turned to assisted reproductive technology; however, the safety of syphilis carrier serostatus on IVF and embryo transfer outcomes has not been evaluated. Data from 482 patients who delivered singletons were analysed. In the retrospective study, the ...

journal_title：Reproductive biomedicine online

authors： Lin S,Li R,Huang S,Zhao L,Li M,Li J,Zhu J,Zheng X,Huang J,Liu P,Qiao J

更新日期：2014-12-01 00:00:00

abstract：:Caesarean scar pregnancy is a dangerous condition that occurs when an embryo is implanted in a previous Caesarean scar. This condition has become more frequent as a direct consequence of the increased number of Caesarean sections reported worldwide. Timely diagnosis of this condition is fundamental, and allows a conse...

journal_title：Reproductive biomedicine online

authors： Mollo A,Alviggi C,Conforti A,Insabato L,De Placido G

更新日期：2014-11-01 00:00:00

abstract：:This study compared the effect on blastocyst development and clinical outcome of coasting in women at increased risk of moderate-severe ovarian hyperstimulation syndrome (OHSS; n=389) with a control group matched for age and basal FSH that did not undergo coasting (n=386) in IVF/intracytoplasmic sperm injection (ICSI)...

journal_title：Reproductive biomedicine online

authors： Talebi Chahvar S,Zosmer A,Caragia A,Balestrini S,Sabatini L,Tranquilli AL,Al-Shawaf T

更新日期：2014-08-01 00:00:00

abstract：:Developmental toxicity caused by exposure to a mixture of environmental pollutants has become a major health concern. Human-made chemicals, including xenoestrogens, pesticides and heavy metals, as well as unhealthy lifestyle behaviours, mainly tobacco smoking, alcohol consumption and medical drug abuse, are major fact...

journal_title：Reproductive biomedicine online

authors： Al-Gubory KH

更新日期：2014-07-01 00:00:00

abstract：:As a member of the homeobox (HOX) gene family, HOXA11 is expressed in the primordia of lower uterus and cervix during fetal life and is essential for endometrial development and embryo implantation in the adults. The aim of the present study was to investigate whether mutations in HOXA11 contribute to Müllerian duct a...

journal_title：Reproductive biomedicine online

authors： Chen X,Li G,Qin Y,Cui Y,You L,Chen ZJ

更新日期：2014-06-01 00:00:00

abstract：:No single or multivariate model is effective for predicting poor ovarian response (POR) with satisfactory sensitivity and specificity. This study investigated whether dehydroepiandrosterone sulphate (DHEAS) or basal testosterone concentrations could be effective predictors of POR defined by the Bologna criteria. This ...

journal_title：Reproductive biomedicine online

authors： Guo J,Zhang Q,Li Y,Huang J,Wang W,Huang L,Zhao X,Yang D

更新日期：2014-06-01 00:00:00

abstract：:This study examined the possible involvement of carbonic anhydrase activation in response to an endometriosis-related increase in oxidative stress. Peripheral blood samples obtained from 27 healthy controls and 30 endometriosis patients, classified as having endometriosis by histological examination of surgical specim...

journal_title：Reproductive biomedicine online

authors： Andrisani A,Donà G,Brunati AM,Clari G,Armanini D,Ragazzi E,Ambrosini G,Bordin L

更新日期：2014-06-01 00:00:00

abstract：:Time-lapse analysis of tripronucleated zygotes obtained in ICSI cycles showed that 75.4% cleaved into embryos. These embryos subsequently demonstrated slower developmental kinetics than normally fertilized embryos. ...

journal_title：Reproductive biomedicine online

authors： Lammers J,Splingart C,Barrière P,Fréour T

更新日期：2014-05-01 00:00:00

abstract：:This study evaluated the cost-effectiveness of treatments for women with polycystic ovary syndrome (PCOS) who ovulate on clomiphene citrate but do not conceive after six cycles. A decision-analytic framework was developed for six scenarios: (1) three cycles of IVF; (2) continuation of clomiphene citrate for six cycles...

journal_title：Reproductive biomedicine online

authors： Moolenaar LM,Nahuis MJ,Hompes PG,van der Veen F,Mol BW

更新日期：2014-05-01 00:00:00

abstract：:Preimplantation genetic diagnosis and screening improves the chances of achieving a viable pregnancy, not only free of undesired single-gene defects but also aneuploidy. In addition, improvements in vitrification provide an efficient means of preserving embryos (blastocysts). By combining trophectoderm biopsy with rec...

journal_title：Reproductive biomedicine online

authors： Adler A,Lee HL,McCulloh DH,Ampeloquio E,Clarke-Williams M,Wertz BH,Grifo J

更新日期：2014-04-01 00:00:00

abstract：:This study investigated the effects of long-term (24h) in-vitro sperm incubation at room temperature (RT; 23°C) versus testis temperature (35°C) on various sperm-quality parameters. Semen samples (n=41) were prepared both by density-gradient centrifugation (DGC) and the swim-up technique in order to compare the influe...

journal_title：Reproductive biomedicine online

authors： Thijssen A,Klerkx E,Huyser C,Bosmans E,Campo R,Ombelet W

更新日期：2014-04-01 00:00:00

abstract：:The use of a gonadotrophin-releasing hormone (GnRH) agonist to trigger final oocyte maturation in a GnRH antagonist protocol has been associated with poorer clinical outcomes due to an increased luteal-phase defect. It has been shown that LH activity is crucial in a normal luteal phase. Studies assessing the LH concen...

journal_title：Reproductive biomedicine online

authors： Derksen L,Tournaye H,Stoop D,Van Vaerenbergh I,Bourgain C,Polyzos NP,Haentjens P,Blockeel C

更新日期：2014-03-01 00:00:00

abstract：:For the gamete and embryo donation community, it is well recognized that the implementation of a gamete and embryo donor registry (GEDR) represents a good initiative to ensure the best possible health conditions for donor-conceived individuals. Be they national, institutional or independent, GEDR can play a major role...

journal_title：Reproductive biomedicine online

authors： Couture V,Dubois MA,Drouin R,Moutquin JM,Bouffard C

更新日期：2014-03-01 00:00:00

abstract：:Tubulin is a protein constituent of cytoskeletal microtubules, closely related to sperm motility. However, the changes in tubulin distribution following capacitation and acrosome reaction are poorly understood. This study immunolocalized and quantified the expression of α-tubulin in fresh, capacitated and acrosome-rea...

journal_title：Reproductive biomedicine online

authors： Francou MM,Ten J,Bernabeu R,De Juan J

更新日期：2014-02-01 00:00:00

abstract：:Present management of the ovarian endometrioma focuses on the size of the cyst and dictates that surgery should not be performed unless this exceeds 3 cm, which neglects the complex pathology of this condition. Studies of ovaries with the endometrioma in situ show progressive smooth muscle cell metaplasia and fibrosis...

journal_title：Reproductive biomedicine online

authors： Brosens I,Gordts S,Puttemans P,Benagiano G

更新日期：2014-02-01 00:00:00

abstract：:Intracytoplasmic morphologically selected sperm injection (IMSI) involves the use of differential interference contrast microscopy at high magnification (at least ·6300) to improve the observation of live human spermatozoa (particularly by showing sperm head vacuoles that are not necessarily seen at lower magnificatio...

journal_title：Reproductive biomedicine online

authors： Boitrelle F,Guthauser B,Alter L,Bailly M,Bergere M,Wainer R,Vialard F,Albert M,Selva J

更新日期：2014-01-01 00:00:00

abstract：:The discovery of cell-free fetal DNA in maternal plasma in 1997 has stimulated a rapid development of non-invasive prenatal testing. The recent advent of massively parallel sequencing has allowed the analysis of circulating cell-free fetal DNA to be performed with unprecedented sensitivity and precision. Fetal trisomi...

journal_title：Reproductive biomedicine online

authors： Lo YM

更新日期：2013-12-01 00:00:00

abstract：:The population attempting pregnancy and having babies is ageing. Gynaecological and obstetric complications worsen with age. Maternity services are struggling. Increasing rates of infertility and complications are not matched by the marvels in the laboratory. This paper argues that assisted reproduction treatment has ...

journal_title：Reproductive biomedicine online

authors： Daly I,Bewley S

更新日期：2013-12-01 00:00:00

abstract：:The purpose of this commentary is to draw attention to some unsatisfactory features in the way that meta-analyses are presented in assisted reproduction journals. These features will be illustrated with reference to recently published papers. An appeal will be made for a more fastidious and rigorous approach to this s...

journal_title：Reproductive biomedicine online

authors： Walters E

更新日期：2013-11-01 00:00:00

abstract：:Implantation requires highly orchestrated interactions between the developing embryo and maternal endometrium. The association between abnormal implantation and reproductive failure is evident, both in normal pregnancy and in assisted reproduction patients. Failure of implantation is the pregnancy rate-limiting step i...

journal_title：Reproductive biomedicine online

authors： Weimar CH,Post Uiterweer ED,Teklenburg G,Heijnen CJ,Macklon NS

更新日期：2013-11-01 00:00:00

abstract：:Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most ...

journal_title：Reproductive biomedicine online

authors： Lewis SE,John Aitken R,Conner SJ,Iuliis GD,Evenson DP,Henkel R,Giwercman A,Gharagozloo P

更新日期：2013-10-01 00:00:00

abstract：:IVF productivity rate is an index defined as the sum of all live births from either fresh or frozen embryo transfers arising from a single oocyte collection. This retrospective analysis over 9 continuous years used this index to understand the potential impact on pregnancy rates of milder stimulation regimens with ass...

journal_title：Reproductive biomedicine online

authors： Stanger JD,Yovich JL

更新日期：2013-09-01 00:00:00

abstract：:Several criteria are being used to restrict access to medically assisted reproduction. In many countries, parental characteristics such as age and sexual orientation are used for this purpose. Valid use of such criteria is hampered by two elements: first, there is no consensus on which features good parents should pos...

journal_title：Reproductive biomedicine online

authors： Pennings G

更新日期：2013-08-01 00:00:00

abstract：:Recent advances in assisted reproduction treatment have enabled some couples with severe infertility issues to conceive, but the methods are not successful in all cases. Notwithstanding the significant financial burden of assisted reproduction treatment, the emotional scars from an inability to conceive a child enacts...

journal_title：Reproductive biomedicine online

authors： Easley CA 4th,Simerly CR,Schatten G

更新日期：2013-07-01 00:00:00

abstract：:This is a commentary on the personal account of Jane Everywoman. It reflects on her experiences and thoughts. The author adds context from her own work with the Progress Educational Trust, the Daisy Network Premature Menopause Support Group and the National Infertility Awareness Campaign. Examples of the mixed message...

journal_title：Reproductive biomedicine online

authors： Norcross S

更新日期：2013-07-01 00:00:00

abstract：:The bi-parental genetic state is not a given after assisted reproduction. This is based on a biological definition of parentage that concerns generational inheritance of genetic material. Often three or more individuals may participate in artificial reproduction. Only cytoplasmic and spindle transfer can result in the...

journal_title：Reproductive biomedicine online

authors： Cohen J,Alikani M

更新日期：2013-06-01 00:00:00

abstract：:Endocrine-disrupting chemicals are substances present in the environment that can interfere with normal hormonal balance and thus exert potentially adverse health effects on the human organism. Male reproductive system development and function may be susceptible to the effects of such environmental toxicants. Bispheno...

journal_title：Reproductive biomedicine online

authors： Knez J

更新日期：2013-05-01 00:00:00

abstract：:Ectopic pregnancy is a known risk for patients treated with IVF. The objective of this study was to evaluate the effect of methotrexate (MTX) and laparoscopic salpingectomy as treatments of ectopic pregnancy on ovarian response during IVF cycles. Data of all women treated for ectopic pregnancy as a result of IVF treat...

journal_title：Reproductive biomedicine online

authors： Wiser A,Gilbert A,Nahum R,Orvieto R,Haas J,Hourvitz A,Weissman A,Younes G,Dirnfeld M,Hershko A,Shulman A,Tsafrir A,Holzer H,Shalom-Paz E,Tulandi T

更新日期：2013-05-01 00:00:00

abstract：:Rescue ICSI can induce a high rate of 3 pronuclei (PN) formation from double insemination in eggs already fertilized by IVF but lacking signs of normal pronuclear formation. This study was performed to determine whether the number of 3PN embryos could be reduced by using the polarization microscope for rescue intracyt...

journal_title：Reproductive biomedicine online

authors： Moon JH,Son WY,Henderson S,Mahfoudh A,Dahan M,Holzer H

更新日期：2013-03-01 00:00:00

abstract：:The concept that a bolus of gonadotrophin-releasing hormone agonist (GnRHa) can replace human chorionic gonadotrophin(HCG) as a trigger of final oocyte maturation was introduced several years ago. Recent developments in the area strengthen this premise. GnRHa trigger offers important advantages, including virtually co...

journal_title：Reproductive biomedicine online

authors： Kol S,Humaidan P

更新日期：2013-03-01 00:00:00

abstract：:This paper reports on and discusses the findings of an online survey initiated by the Donor Sibling Registry of 108 parents of children conceived following oocyte donation. Respondents generally supported early disclosure of donor conception to the child, although some bias in favour of disclosure cannot be excluded, ...

journal_title：Reproductive biomedicine online

authors： Blyth E,Kramer W,Schneider J

更新日期：2013-02-01 00:00:00

abstract：:This commentary discusses the decision in S.H. and Others v. Austria from a political theoretical and bioethical perspective. I focus on the opinion's discussion of what I call 'circumvention tourism', travelling abroad for the purpose of circumventing domestic prohibitions, especially as to medical services. The majo...

journal_title：Reproductive biomedicine online

authors： Glenn Cohen I

更新日期：2012-12-01 00:00:00

abstract：:Traditional dogma suggests that intracytoplasmic sperm injection (ICSI) should be performed to ensure successful oocyte fertilization in an in-vitro maturation (IVM) cycle. This study postulated that there would be no difference in the fertilization rate when ICSI was compared with IVF. This hypothesis was tested in a...

journal_title：Reproductive biomedicine online

authors： Walls M,Junk S,Ryan JP,Hart R

更新日期：2012-12-01 00:00:00

abstract：:It remains controversial whether anti-Müllerian hormone (AMH) concentration is influenced by hormonal contraception. This study quantified the effect of hormonal contraception on both endocrine and sonographic ovarian reserve markers in 228 users and 504 non-users of hormonal contraception. On day 2-5 of the menstrual...

journal_title：Reproductive biomedicine online

authors： Bentzen JG,Forman JL,Pinborg A,Lidegaard Ø,Larsen EC,Friis-Hansen L,Johannsen TH,Nyboe Andersen A

更新日期：2012-12-01 00:00:00

abstract：:Preimplantation genetic diagnosis (PGD) is an increasingly common adjunct to IVF. The information gained from PGD may be used to reduce the incidence of chromosomally abnormal pregnancies and augment the current selection process of embryos. As such, patients may choose to utilize PGD in either fresh or cryopreserved ...

journal_title：Reproductive biomedicine online

authors： Lathi RB,Massie JA,Gilani M,Milki AA,Westphal LM,Baker VL,Behr B

更新日期：2012-11-01 00:00:00

abstract：:Cleavage kinetics of human embryos is indicative of ability to develop to blastocyst and implant. Recent advances in time-lapse microscopy have opened new and important research opportunities. In this study involving infertile couples requiring standard IVF/intracytoplasmic sperm injection treatment, zygotes were cult...

journal_title：Reproductive biomedicine online

authors： Dal Canto M,Coticchio G,Mignini Renzini M,De Ponti E,Novara PV,Brambillasca F,Comi R,Fadini R

更新日期：2012-11-01 00:00:00